Is there an ACE ID - ACTN3 R577X polymorphisms interaction that influences sprint performance?

Full text for this resource is not available from the Research Repository.

Eynon, Nir ORCID: 0000-0003-4046-8276, Alves, Alberto Jorge, Yamin, Chen, Sagiv, Moran, Duarte, Jose, Oliveira, Jose, Ayalon, Moshe, Goldhammer, Ehud, Sagiv, Michael and Meckel, Yoav (2009) Is there an ACE ID - ACTN3 R577X polymorphisms interaction that influences sprint performance? International Journal of Sports Medicine, 30 (12). pp. 888-891. ISSN 0172-4622

Abstract

Functional R577X (rs.1815739) and ID (rs.5186) polymorphisms in the α -actinin-3 ( ACTN3 ) and the angiotensin converting enzyme (ACE) genes, respectively, have been associated with sprint performance. The aim of this study was to determine their eff ect on sprint performance among 81 Israeli sprinters and 240 healthy controls. Results revealed that the ACE II genotype + ACTN3 R allele (P = 0.003 for sprinters vs. controls), and the ACTN3 RR genotype + ACE I allele (P = 0.001 for sprinters vs. controls) might be the genotype for sprinters. In the whole cohort the probability of ACTN3 RR genotype + ACE I allele being a sprinter (odds ratio 2.67, 95 % confidence interval 1.45 – 4.93) and of ACE II genotype + ACTN3 R allele being a sprinter (odds ratio 3.57, 95 % confidence interval 1.78 – 7.15) was significantly higher than that in the controls. In conclusion, the above data suggest that ACE ID / ACTN3 R577X genotype combination is associated with sprint ability. However, ACE ID / ACTN3 R577X genotype combination is not related to the level of performance.

Dimensions Badge

Altmetric Badge

Item type Article
URI https://vuir.vu.edu.au/id/eprint/10492
DOI https://doi.org/10.1055/s-0029-1238291
Official URL https://www.thieme-connect.com/ejournals/html/10.1...
Subjects Current > FOR Classification > 0604 Genetics
Current > FOR Classification > 1106 Human Movement and Sports Science
Historical > Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Keywords ResPubID25128, genotype frequencies, genetics, top-level athletes
Citations in Scopus 26 - View on Scopus
Download/View statistics View download statistics for this item

Search Google Scholar

Repository staff login