CK-MM gene polymorphism does not influence the blood CK activity levels after exhaustive eccentric exercise

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Yamin, Chen, Oliveira, Jose, Meckel, Yoav, Eynon, Nir ORCID: 0000-0003-4046-8276, Sagiv, Moran, Avalon, M, Alves, Alberto Jorge and Duarte, Jose (2010) CK-MM gene polymorphism does not influence the blood CK activity levels after exhaustive eccentric exercise. International Journal of Sports Medicine, 31 (3). pp. 213-217. ISSN 0172-4622


Gene variants, such as creatine kinase (CK) polymorphisms, have been suggested to explain the inter-individual blood CK response to eccentric exercise. However, since this association is still doubtful, the purpose of this study was to analyse the relationship between the magnitudes of the CK response to exercise with the occurrence of muscle CK-MM NcoI polymorphism in young healthy subjects. Blood CK activity was assessed in 70 subjects immediately before and 3, 24, 48,72, 96, 120, 168 h after strenuous eccentric exercise. Based on the amount of CK release by each subject, the sample was distributed in quartiles and the genotype and allele frequency distribution was compared among quartiles. Despite the inter-individual variability of CK response observed between subjects, there were no diff erences in genotype and allele frequencies among quartiles. The results allowed us to conclude that CK response after exhaustive eccentric exercise is not associated with CK-MM Ncol polymorphism.

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Item type Article
DOI 10.1055/s-0029-1243256
Official URL
Subjects Historical > FOR Classification > 1102 Cardiorespiratory Medicine and Haematology
Historical > FOR Classification > 1106 Human Movement and Sports Science
Historical > Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Keywords ResPubID25139, quartiles, genotype, inter-individual variability, muscle damage, CK activity, CK-MM Ncol polymorphism
Citations in Scopus 10 - View on Scopus
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