Do PPARGC1A and PPAR alpha polymorphisms influence sprint or endurance phenotypes?

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Eynon, Nir ORCID: 0000-0003-4046-8276, Meckel, Yoav, Sagiv, Moran, Yamin, Chen, Amir, Ruthie E, Sagiv, Michael, Goldhammer, Ehud, Duarte, Jose and Oliveira, Jose (2010) Do PPARGC1A and PPAR alpha polymorphisms influence sprint or endurance phenotypes? Scandinavian Journal of Medicine and Science in Sports, 20 (1). e145-e150. ISSN 0905-7188 (print) 1600-0838 (online)


The aim of this study was to determine their frequency distribution among 155 Israeli athletes (endurance athletes and sprinters) and 240 healthy controls. Results showed that there was a significant difference in PPARGC1A Ser482Gly polymorphism genotype frequencies between endurance athletes and sprinters (P50.005) as well as between endurance athletes and controls (P50.0003). However, the sprinters’ genotype and allele frequencies were similar to that of the control group. A significantly lower proportion of PPARGC1A Ser482 allele (0.25) was noted for the endurance athletes compared with controls (0.43, P50.0001). Endurance athletes showed a trend of a higher yet a not significant proportion of the PPAR alpha GG genotype compared with sprinters (P50.051). As we compared between the subgroups of top-level endurance athletes and top-level sprinters, as well as between those of top-level and national-level endurance athletes, we reached more prominent results. In conclusion, our data indicate that a lower frequency of the Ser482 allele and possibly a higher frequency of the GG genotype are associated with increased endurance performance ability.

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Item type Article
DOI 10.1111/j.1600-0838.2009.00930.x
Official URL
Subjects Historical > FOR Classification > 0604 Genetics
Historical > FOR Classification > 1106 Human Movement and Sports Science
Historical > Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Keywords ResPubID25140, elite athletic performance, mitochondrial biogenesis, single nucleotide polymorphisms, SNPs, genotype frequencies, allele frequencies, genomic DNA, talent identification, aerobic performance, anaerobic performance, metabolism
Citations in Scopus 68 - View on Scopus
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