Effects of Exercise and Angiotensin-Converting Enzyme (ACE) on Aortic Stiffness in the Elderly

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Sagiv, Moran, Eynon, Nir ORCID: 0000-0003-4046-8276, Sagiv, Michael, Yamin, Chen and Alves, Alberto Jorge (2010) Effects of Exercise and Angiotensin-Converting Enzyme (ACE) on Aortic Stiffness in the Elderly. Archives of Exercise in Health and Disease, 1 (1). pp. 3-11. ISSN 1647-1652


Senescence is a complex process involving many variables including genetics, lifestyle factors, and chronic diseases, the interaction of which significantly influences the manner in which we age (2). In particular, hypertension and genes of the rennin-angiotensin-aldosterone system have been associated with functional and structural changes of the large arteries, which are thought to contribute to age-related increases in the incidence of cardiovascular disease. Despite mounting evidence implicating sedentary behavior as a significant risk factor in chronic-disease morbidity and mortality among the elderly, there is a limited amount of information on the role of exercise in promoting optimal health and function in older people (27). The purpose of the present review is to discuss the effects of exercise training and angiotensin-converting enzyme (ACE) on aortic stiffness in the elderly.

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Review manuscript

Item type Article
URI https://vuir.vu.edu.au/id/eprint/10507
Official URL http://ciafel.fade.up.pt/aehd/index.php/aehd/artic...
Subjects Historical > FOR Classification > 1102 Cardiorespiratory Medicine and Haematology
Historical > FOR Classification > 1106 Human Movement and Sports Science
Historical > Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Keywords ResPubID25143, aortic elasticity, angiotensin-converting enzyme, hypertension, genotype, exercise
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