Steric aspects of the interaction of metal species with nucleic acid constituents

Yuriev, Elizabeth (1997) Steric aspects of the interaction of metal species with nucleic acid constituents. PhD thesis, Victoria University of Technology.

Abstract

The delineation of steric effects in the interaction of metal species with biomolecules has been addressed. More specifically, a focus has been placed on the interaction of platinum complexes with nucleoconstituents. Steric effects thus characterised have been related to the biological properties of such complexes. Steric aspects of metal complex speciation have been investigated both from experimental and theoretical viewpoints. Manipulation of steric effects within model systems has been carried out by way of judicious ligand design.

Item type Thesis (PhD thesis)
URI https://vuir.vu.edu.au/id/eprint/15393
Subjects Current > FOR Classification > 0305 Organic Chemistry
Current > FOR Classification > 0601 Biochemistry and Cell Biology
Historical > Faculty/School/Research Centre/Department > School of Engineering and Science
Keywords DNA-ligand interactions, platinum compounds, sterochemistry, metal complexes
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