Determining clinically relevant neuropsychological change in an epilepsy sample

Cumner, Marnie (2009) Determining clinically relevant neuropsychological change in an epilepsy sample. Other Degree thesis, Victoria University.


Accurate interpretation of pre- and post-surgical cognitive assessments is essential for patients undergoing surgery for temporal lobe epilepsy (TLE). However, potentially confounding issues such as practice effects and low test-retest reliability may influence a person’s test score when they are given the same neuropsychological test on a second occasion, such as following surgery. Determining how much change in test scores is due to methodological issues and how much is due to genuine post-operative cognitive improvement or decline can better inform both clinical and client decisions regarding surgical intervention for TLE. Such data has been reported in North American TLE populations but the generalisability of this data to other centres is unknown. Using data obtained from unoperated patients with TLE, the current study utilised standardised regression-based change (SRB) and reliable change index (RCI) methodologies to determine change on retest across cognitive domains. Both the local and North American RCIs and SRB change norms were then applied to an Australian post-operative sample to evaluate cognitive outcomes, as well as to investigate the generalisability of change data derived from different demographic backgrounds.

Additional Information

Doctor of Psychology (Clinical Neuropsychology)

Item type Thesis (Other Degree thesis)
Subjects Historical > FOR Classification > 1701 Psychology
Historical > Faculty/School/Research Centre/Department > School of Social Sciences and Psychology
Keywords Neurophysical changes, Temporal lobe epilepsy, Standardised regression-based change, Cognition, Reliable change index methodologies
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