The development of peptide-based inhibitors of the low affinity Fc receptor, Fc [gamma] RIIa

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Cendron, Angela (2005) The development of peptide-based inhibitors of the low affinity Fc receptor, Fc [gamma] RIIa. PhD thesis, Victoria University of Technology.

Abstract

FcyRIIa is an activatory receptor and contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain, involved in the initiation of signalling events. There is now strong evidence from transgenic mouse models and human genetic susceptibility studies that implicate FcyRIIa in a number of immune diseases including, rheumatoid arthritis, systemic lupus erythematosus (SLE) and immune thrombocytopenia purpura (ITP). FcyRHa is therefore a promising target for the development of therapeutics to treat these diseases.

Item type Thesis (PhD thesis)
URI http://vuir.vu.edu.au/id/eprint/15580
Subjects Current > FOR Classification > 1107 Immunology
Historical > Faculty/School/Research Centre/Department > School of Engineering and Science
Keywords Fc receptors, Immune response, Regulation, Chemical inhibitors, peptides, immune thrombocytopenia purpura, lupus erythematosus, rheumatoid arthritis, immunoreceptors, immune diseases
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