Investigation of the oxytocin receptor gene in sheep

Feng, Helen Chunying (2000) Investigation of the oxytocin receptor gene in sheep. PhD thesis, Victoria University of Technology.


The increase in uterine oxytocin receptor (OTR)concentrations over the late luteal phase of the estrous cycle in sheep is thought to play an important role in the regulation of the cycle length by facilitating the effect of oxytocin on uterine prostaglandin release. At the end of pregnancy, a dramatic increase in the number of OTR also indicates the importance for OTR in the process of labor. In order to study the mechanisms underlying the resolution of OTR expression, the aim of this study was to obtain and characterise OTR cDNA and OTR gene transcripts, to determine the OTR gene expression level in different tissue types, to investigate the role of exogenous steroids in the regulation of OTR gene expression, and to develop a gene expression system for OTR protein.

Item type Thesis (PhD thesis)
Subjects Historical > FOR Classification > 0702 Animal Production
Historical > FOR Classification > 0604 Genetics
Historical > Faculty/School/Research Centre/Department > School of Engineering and Science
Keywords Ewes, Reproduction, Oxytocin, prostaglandin, uterine, estrous cycle, sheep, pregnancy, genes, animal reproduction
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