Factors affecting the excitability of skinned fibres of the rat

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Goodman, Craig ORCID: 0000-0002-5874-7743 (2003) Factors affecting the excitability of skinned fibres of the rat. PhD thesis, Victoria University.


During the last decade, the rat mechanically skinned fibre preparation has been used with increasing frequency to investigate cellular aspects of excitation-contraction (EC) coupling processes in mammalian skeletal muscle. The main aim of this thesis was to increase awareness of factors that affect the contractile responsiveness of rat mechanically skinned fibre preparations to T-system depolarization, a functional parameter of E-C coupling referred to, sometimes, as skinned fibre excitability. More specifically, the work presented in this thesis is concerned with the relationship between rat skinned fibre excitability and (i) developmental age, (ii) MHC composition, muscle of origin and (iii) glycogen content.

Item type Thesis (PhD thesis)
URI https://vuir.vu.edu.au/id/eprint/15598
Subjects Historical > FOR Classification > 1004 Medical Biotechnology
Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Keywords Muscle contraction, Rats, Muscles
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