Levinger, Itamar (2008) The effects of resistance training on individuals with clusters of metabolic risk factors: focus on functional capacities, clinical outcomes and quality of life. PhD thesis, Victoria University.

Abstract

The prevalence of high numbers of metabolic risk factors (HiMF) associated with the metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) has increased considerably over the past two decades. Lifestyle factors including physical inactivity are major components in the development of HiMF. Middle-aged individuals with HiMF and T2DM are commonly characterised by reductions in muscle strength, muscle mass and also lower capacities to perform activities of daily living (ADL's), compared to individuals with low numbers of metabolic risk factors (LoMF). Study one investigated the differences in some characteristics between individuals with HiMF and LoMF. Study two compared the effects of 10 weeks of resistance exercise training (RT) on the capacity to perform ADL's and QoL for middle aged individuals with HiMF and LoMF. Study three examined the effect of RT on conventional and emerging metabolic risk factors for individuals with HiMF and LoMF. The final study investigated the effects of RT on the insulin signalling proteins, Akt (protein kinase B) and Akt substrate of 160 kDa (AS 160), and muscle glycogen stores for individuals with HiMF or LoMF.

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