The effects of N-acetylcysteine infusion on performance, glutathione and ion regulation during voluntary exercise in humans

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Medved, Ivan (2005) The effects of N-acetylcysteine infusion on performance, glutathione and ion regulation during voluntary exercise in humans. PhD thesis, Victoria University of Technology.

Abstract

The production of reactive oxygen species in skeletal muscle has been linked with muscle fatigue. Infusion of the antioxidant compound 7V-acetylcysteine (NAC) reduced fatigability in electrically evoked human muscle contractions, but numerous adverse reactions were reported. No studies have investigated NAC infusion effects during voluntary exercise in humans. This thesis investigated whether an NAC infusion protocol that was modified to minimise these adverse reactions, would augment time to fatigue, enhance glutathione availability and enhance potassium (K+) regulation during voluntary fatiguing exercise.

Item type Thesis (PhD thesis)
URI https://vuir.vu.edu.au/id/eprint/15641
Subjects Historical > FOR Classification > 1116 Medical Physiology
Historical > Faculty/School/Research Centre/Department > School of Sport and Exercise Science
Historical > FOR Classification > 1106 Human Movement and Sports Science
Keywords Exercise, Muscles, Fatigue, antioxidants, glutathione, ion regulation, n-acetylcysteine
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