Molecular basis of Fce receptor: IgE interactions

Rigby, Aveline Joan (2001) Molecular basis of Fce receptor: IgE interactions. PhD thesis, Victoria University of Technology.


Allergic diseases such as asthma and hay fever cause distress to numerous individuals throughout the world, sometimes with fatal consequences. Many associated costs - physical absences, psychological corollaries or medication - are borne by the community via health agencies or the government. The symptoms of these diseases, such as inflammation of the airways, are initially caused by the apposite allergen crosslinking at least two molecules of IgE bound to their high-affinity cell surface receptor FceRI. This interaction initiates intracellular signalling starting a cascade of events resulting in cellular degranulation and the release of inflammatory mediators. Many present treatments for these conditions act at this stage to inhibit the activity of these chemical intermediaries, after inflammation has been initiated. This thesis specifically addresses the high-affinity receptor for IgE (a chain) - FceRI-a, chimeric receptors of FceRI-a and FcyRIIa, with FceRI-a point mutants, and their interaction with IgE.

Item type Thesis (PhD thesis)
Subjects Historical > FOR Classification > 1107 Immunology
Historical > Faculty/School/Research Centre/Department > School of Engineering and Science
Historical > FOR Classification > 0304 Medicinal and Bimolecular Chemistry
Keywords Fc receptors, Immunoglobulin E, inhibitators, receptors, allergens
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