Dietary and exercise manipulation of skeletal muscle function in older humans

Smith, Graeme (2010) Dietary and exercise manipulation of skeletal muscle function in older humans. PhD thesis, Victoria University.


Although life expectancy is increasing, this often comes at the cost of declining health through an increased incidence of cancer, cardiovascular disease and arthritis in older age. In addition, a decline in muscular performance is commonly observed with increasing age, combining a loss of skeletal muscle (‘sarcopenia’), a decrease in muscle oxidative capacity and a reduction in muscle strength. Research has shown that it is possible to arrest, or even reverse, the changes in muscle mass and oxidative capacity that occur with age. Two of the most successful strategies identified to date in this regard are exercise, in particular resistance-based training, and protein supplementation. We devised a series of four related studies to investigate and refine strategies for the prevention or mitigation of sarcopenia among the elderly.

Item type Thesis (PhD thesis)
Subjects Historical > FOR Classification > 1111 Nutrition and Dietetics
Historical > FOR Classification > 1106 Human Movement and Sports Science
Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Keywords dietary manipulation, exercise manipulation, diet, exercise, skeletal muscle, muscle function, muscle structure, elderly, aging, muscular performance, muscle strength, oxidative capacity, muscle mass, resistance-based training, sarcopenia, obesity, mitochondria, nutritional therapy, protein, supplements, diet, muscles, redox
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