Role of angiotensin II in the hypertension induced by renal artery stenosis

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Anderson, W. P, Selig, Steve E and Korner, P. I (1984) Role of angiotensin II in the hypertension induced by renal artery stenosis. Clinical and Experimental Hypertension, 6 (1-2). pp. 299-314. ISSN 1064-1963


Identical degrees of renal artery stenosis were induced in 5 dogs on two separate occasions; once during continuous inhibition of angiotensin I converting enzyme with enalapril, and once with the dogs untreated. Arterial pressure rose about 25 mm Hg during 3 days of stenosis in untreated dogs, due to increased total peripheral resistance. When the dogs were treated with enalapril, blood pressure had risen 14.5 +/- 3.4 mm Hg 24 hours after stenosis due to a 35% increase in cardiac output while total peripheral resistance fell by 16%. By the third day, blood pressure had returned to pre-stenosis levels, cardiac output was close to normal and total peripheral resistance had increased. The stenosis on the renal artery increased the resistance to blood flow of the kidneys in both untreated and enalapril treated dogs. This increase in kidney resistance in the untreated dogs accounted for about 30% of the change in total peripheral resistance. In the enalapril treated dogs, the increased kidney resistance helped offset the vasodilatation in the rest of the vasculature. These results suggest that angiotensin II mediated vasoconstriction of nonrenal vascular beds was responsible for about 2/3 of the hypertension following renal artery stenosis, and the resistance of the stenosis responsible for about 1/3.

Item type Article
Subjects Historical > RFCD Classification > 320000 Medical and Health Sciences
Historical > Faculty/School/Research Centre/Department > School of Sport and Exercise Science
Keywords angiotensin II, stenosis, renal artery
Citations in Scopus 12 - View on Scopus
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