Docosapentaenoic acid (22:5n-3): a review of its biological effects

[img]
Preview
Revised_manuscript_gkaur3.pdf - Accepted Version (354kB)

Kaur, Gunveen, Cameron-Smith, David, Garg, Manohar and Sinclair, Andrew J (2011) Docosapentaenoic acid (22:5n-3): a review of its biological effects. Progress in Lipid Research, 50 (1). pp. 28-34. ISSN 0163-7827 (print), 1832-2194 (online)

Abstract

This article summarizes the current knowledge available on metabolism and the biological effects of n-3 docosapentaenoic acid (DPA). n-3 DPA has not been extensively studied because of the limited availability of the pure compound. n-3 DPA is an elongated metabolite of EPA and is an intermediary product between EPA and DHA. The literature on n-3 DPA is limited, however the available data suggests it has beneficial health effects. In vitro n-3 DPA is retro-converted back to EPA, however it does not appear to be readily metabolised to DHA. In vivo studies have shown limited conversion of n-3 DPA to DHA, mainly in liver, but in addition retro-conversion to EPA is evident in a number of tissues. n-3 DPA can be metabolised by lipoxygenase, in platelets, to form ll-hydroxy-7,9,13,16,19- and 14-hydroxy-7,10,12,16,19-DPA. It has also been reported that n-3 DPA is effective (more so than EPA and DHA) in inhibition of aggregation in platelets obtained from rabbit blood. In addition, there is evidence that n-3 DPA possesses 10-fold greater endothelial cell migration ability than EPA, which is important in wound-healing processes. An in vivo study has reported that n-3 DPA reduces the fatty acid synthase and malic enzyme activity levels in n-3 DPA-supplemented mice and these effects were stronger than the EPA-supplemented mice. Another recent in vivo study has reported that n-3 DPA may have a role in attenuating age-related decrease in spatial learning and long-term potentiation. However, more research remains to be done to further investigate the biological effects of this n-3 VLCPUFA.

Dimensions Badge

Altmetric Badge

Item type Article
URI https://vuir.vu.edu.au/id/eprint/21393
DOI https://doi.org/10.1016/j.plipres.2010.07.004
Official URL http://www.sciencedirect.com/science/article/pii/S...
Subjects Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Historical > Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Keywords n-3 Polyunsaturated fatty acids, VLCPUFA, eicosapentaenoic acid, EPA, docosapentaenoic acid, DPA, docosahexaenoic acid, DHA, lipids
Citations in Scopus 224 - View on Scopus
Download/View statistics View download statistics for this item

Search Google Scholar

Repository staff login