Leptin Stimulation of COXIV is Impaired in Obese Skeletal Muscle Myotubes

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McAinch, Andrew ORCID: 0000-0002-8762-4865, Steinberg, G. R, Mollica, Janelle, O'Brien, Paul E, Dixon, JB, Kemp, Bruce E and Cameron-Smith, David (2007) Leptin Stimulation of COXIV is Impaired in Obese Skeletal Muscle Myotubes. Obesity Research and Clinical Practice, 1 (1). pp. 53-60. ISSN 1871-403X


The principle finding of this study is the further demonstration of the metabolic inflexibility of skeletal muscle myotubes developed from morbidly obese individuals. It was demonstrated that the acute exposure of cultured skeletal muscle myotubes derived from obese individuals to leptin failed to alter the expression of several key lipid oxidative and mitochondrial genes. Contrary to the obese derived myotubes, cells derived from lean and healthy controls demonstrated a capacity to increase the expression of several key genes. Further analysis is required to elucidate the mechanisms involved, with studies needed to examine leptin-receptor mediated events.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/21495
DOI 10.1016/j.orcp.2006.10.003
Official URL http://www.sciencedirect.com/science/article/pii/S...
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Historical > FOR Classification > 1103 Clinical Sciences
Keywords ResPubID14436, human obesity, leptin resistance, mRNA, fat metabolism, PDK4, skeletal muscle, fatty acid oxidation and mitochondrial biogenesis, cultured skeletal muscle myotubes, mitochondrial gene
Citations in Scopus 9 - View on Scopus
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