The expression of receptors for endocannabinoids in human and rodent skeletal muscle

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Cavuoto, Paul, McAinch, Andrew ORCID: 0000-0002-8762-4865, Hatzinikolas, George, Janovska, Alena, Game, Philip and Wittert, Gary (2007) The expression of receptors for endocannabinoids in human and rodent skeletal muscle. Biochemical and Biophysical Research Communications, 364 (1). pp. 105-110. ISSN 0006-291X

Abstract

In this study, have demonstrated the expression of CB2 and TRPV1 in human and rodent skeletal muscle as potential receptor sites for the previously observed effects of AEA [19]. Drugs targeting CB1, CB2, FAAH and TRPV1 for the treatment of obesity, pain and inflammation are currently under development [26,42–44]. The expression of CB2, FAAH and TRPV1 along with CB1 in human and rodent skeletal muscle istherefore an important consideration in the development of these therapeutic targets. Endocannabinoids may have a complex role in skeletal muscle biology.

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Item type	Article
URI	https://vuir.vu.edu.au/id/eprint/21498
DOI	10.1016/j.bbrc.2007.09.099
Official URL	http://dx.doi.org/10.1016/j.bbrc.2007.09.099
Subjects	Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics Historical > FOR Classification > 1103 Clinical Sciences
Keywords	ResPubID14439, endocannabinoids, skeletal muscle biology, lipid derived signalling system, fatty acid amide hydrolase, FAAH, transient receptor potential channel-vanilloid sub-family member 1, TRPV1, cannabinoid receptor type 1, CB1, cannabinoid receptor type 2, CB2, reverse transcription polymerase chain reaction, RT-PCR
Citations in Scopus	138 - View on Scopus
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