Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamps

Stepto, Nigel, Cassar, Samantha, Joaham, Anju E, Hutchison, Samantha K, Harrison, Cheryce L, Goldstein, Rebecca F and Teede, Helena J (2013) Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamps. Human Reproduction, 28 (3). pp. 777-784. ISSN 0268-1161 (print), 1460-2350 (online)

Abstract

What is the prevalence of insulin resistance (IR) and the contributions of intrinsic and extrinsic IR in women diag- nosed with polycystic ovary syndrome (PCOS) according to the Rotterdam criteria? We report novel clamp data in Rotterdam diagnosed PCOS women, using World Health Organization criteria for IR showing that women with PCOS have a high prevalence of IR, strengthening the evidence for an aetiological role of IR in both National Institutes of Health (NIH) and Rotterdam diagnosed PCOS in lean and overweight women.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/21733
DOI https://doi.org/10.1093/humrep/des463
Official URL https://academic.oup.com/humrep/article/28/3/777/9...
Funders http://purl.org/au-research/grants/nhmrc/606553
Subjects Current > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Current > FOR Classification > 1114 Paediatrics and Reproductive Medicine
Historical > Faculty/School/Research Centre/Department > School of Sport and Exercise Science
Keywords PCOS, BMI, visceral fat, hyperandrogenism, females, ovaries, euglycimic-hyperinsulimic clamps, overweight women, body mass index, diabetes
Citations in Scopus 309 - View on Scopus
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