The cannabinoid receptor 1 and its role in influencing peripheral metabolism

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O'Keefe, Lannie, Simcocks, Anna C, Hryciw, Deanne H, Mathai, Michael ORCID: 0000-0001-8783-2122 and McAinch, Andrew ORCID: 0000-0002-8762-4865 (2013) The cannabinoid receptor 1 and its role in influencing peripheral metabolism. Diabetes, Obesity and Metabolism. ISSN 1463-1326

Abstract

Evidence from in vitro and in vivo studies has demonstrated the deleterious pathological effects of a dysregulated endocannabinoid system. Increased stimulation of the cannabinoid receptor 1 (CB1) and subsequent downstream cellular signalling are both causative in the deleterious pathological effects observed in a number of diseases. When the CB1 cell signalling cascade is blocked, this results in whole body weight-loss, leading to a reduction in obesity and associated co-morbidities. In the central nervous system; however, CB1 antagonism results in adverse psychological side effects. Blockade of CB1 via peripheral acting compounds that do not cross the blood–brain barrier have been determined to have beneficial effects in metabolic tissues such as the liver and skeletal muscle. These results support the notion that peripheral blockade of CB1 using pharmacological antagonists is a viable target for the treatment of the current epidemic of obesity and its associated co-morbidities.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/21982
DOI https://doi.org/10.1111/dom.12144
Official URL http://onlinelibrary.wiley.com/doi/10.1111/dom.121...
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Current > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Current > FOR Classification > 1103 Clinical Sciences
Current > FOR Classification > 1111 Nutrition and Dietetics
Keywords cannabinoids, energy regulation, obesity therapy, weight loss therapy, appetite, energy metabolism, endocannabinoid system, ECS, mRNA expression
Citations in Scopus 23 - View on Scopus
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