S-Glutathionylation of troponin I (fast) increases contractile apparatus Ca 2+ sensitivity in fast-twitch muscle fibres of rats and humans

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Mollica, JP, Dutka, TL, Merry, TL, Lamboley, Cedric ORCID: 0000-0002-4008-4929, McConell, Glenn ORCID: 0000-0002-8572-9065, McKenna, Michael ORCID: 0000-0001-9998-0093, Murphy, RM and Lamb, GD (2012) S-Glutathionylation of troponin I (fast) increases contractile apparatus Ca 2+ sensitivity in fast-twitch muscle fibres of rats and humans. Journal of Physiology, 590 (6). pp. 1443-1463. ISSN 0022-3751

Abstract

This study demonstrates that the increase in force response appears to be due to a specific chemical process, known as S-glutathionylation, of a particular cysteine residue present on the troponin I molecule in fast-twitch muscle fibres, which is involved in sensing and responding to changes in intracellular calcium levels.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/22096
DOI https://doi.org/10.1113/jphysiol.2011.224535
Official URL http://jp.physoc.org/content/590/6/1443.full.pdf
Funders http://purl.org/au-research/grants/nhmrc/541938
Subjects Current > FOR Classification > 1116 Medical Physiology
Historical > Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Current > Division/Research > College of Sports and Exercise Science
Keywords ResPubID25388, force response, cysteine residues, oxidation, skinned muscle fibres
Citations in Scopus 69 - View on Scopus
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