Stage of perinatal development regulates skeletal muscle mitochondrial biogenesis and myogenic regulatory factor genes with little impact of growth restriction or cross-fostering
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Laker, Rhianna C, Wadley, Glenn D, McConell, Glenn 
ORCID: 0000-0002-8572-9065 and Wlodek, Mary E
(2012)
Stage of perinatal development regulates skeletal muscle mitochondrial biogenesis and myogenic regulatory factor genes with little impact of growth restriction or cross-fostering.
Journal of Developmental Origins of Health and Disease, 3 (1).
pp. 39-51.
ISSN 2040-1744
Abstract
We hypothesized that key genes involved in muscle development and mitochondrial biogenesis would be altered following uteroplacental insufficiency in rat pups, and improving postnatal nutrition by cross-fostering would ameliorate these deficits. Developmental age appears to be a major factor regulating skeletal muscle mitochondrial and developmental genes, with growth restriction and cross-fostering having only subtle effects. It therefore appears that reductions in adult mitochondrial biogenesis markers likely develop after weaning.
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| Item type | Article |
| URI | https://vuir.vu.edu.au/id/eprint/22104 |
| DOI | 10.1017/S204017441100064X |
| Official URL | http://journals.cambridge.org/action/displayAbstra... |
| Funders | http://purl.org/au-research/grants/nhmrc/454570 |
| Subjects | Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences Historical > FOR Classification > 0601 Biochemistry and Cell Biology Historical > FOR Classification > 0604 Genetics Current > Division/Research > College of Sports and Exercise Science |
| Keywords | ResPubID25781, gene expression, growth, growth restriction, skeletal muscle |
| Citations in Scopus | 5 - View on Scopus |
| Download/View statistics | View download statistics for this item |
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