Stage of perinatal development regulates skeletal muscle mitochondrial biogenesis and myogenic regulatory factor genes with little impact of growth restriction or cross-fostering

Full text for this resource is not available from the Research Repository.

Laker, Rhianna C, Wadley, Glenn D, McConell, Glenn ORCID: 0000-0002-8572-9065 and Wlodek, Mary E (2012) Stage of perinatal development regulates skeletal muscle mitochondrial biogenesis and myogenic regulatory factor genes with little impact of growth restriction or cross-fostering. Journal of Developmental Origins of Health and Disease, 3 (1). pp. 39-51. ISSN 2040-1744

Abstract

We hypothesized that key genes involved in muscle development and mitochondrial biogenesis would be altered following uteroplacental insufficiency in rat pups, and improving postnatal nutrition by cross-fostering would ameliorate these deficits. Developmental age appears to be a major factor regulating skeletal muscle mitochondrial and developmental genes, with growth restriction and cross-fostering having only subtle effects. It therefore appears that reductions in adult mitochondrial biogenesis markers likely develop after weaning.

Dimensions Badge

Altmetric Badge

Item type Article
URI https://vuir.vu.edu.au/id/eprint/22104
DOI https://doi.org/10.1017/S204017441100064X
Official URL http://journals.cambridge.org/action/displayAbstra...
Funders http://purl.org/au-research/grants/nhmrc/454570
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Current > FOR Classification > 0601 Biochemistry and Cell Biology
Current > FOR Classification > 0604 Genetics
Current > Division/Research > College of Sports and Exercise Science
Keywords ResPubID25781, gene expression, growth, growth restriction, skeletal muscle
Citations in Scopus 4 - View on Scopus
Download/View statistics View download statistics for this item

Search Google Scholar

Repository staff login