The emerging role of PEDF in stem cell biology

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Elahy, Mina, Baindur-Hudson, Swati and Dass, Crispin R (2012) The emerging role of PEDF in stem cell biology. Journal of Biomedicine and Biotechnology, 2012. ISSN 1110-7243 (print), 1110-7251 (online)

Abstract

Encoded by a single gene, PEDF is a 50 kDa glycoprotein that is highly conserved and is widely expressed among many tissues. Most secreted PEDF deposits within the extracellular matrix, with cell-type-specific functions. While traditionally PEDF is known as a strong antiangiogenic factor, more recently, as this paper highlights, PEDF has been linked with stem cell biology, and there is now accumulating evidence demonstrating the effects of PEDF in a variety of stem cells, mainly in supporting stem cell survival and maintaining multipotency.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/23162
DOI 10.1155/2012/239091
Official URL http://www.hindawi.com/journals/bmri/2012/239091/
Subjects Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Current > Division/Research > College of Health and Biomedicine
Keywords ResPubID25815, stem cells, proteins, tissues, pigment-epithelium-derived factor
Citations in Scopus 16 - View on Scopus
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