The fate of bone marrow-derived cells carrying a polycystic kidney disease mutation in the genetically normal kidney
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Verghese, Elizabeth, Johnson, Chad, Bertram, John, Ricardo, Sharon D and Deane, James (2012) The fate of bone marrow-derived cells carrying a polycystic kidney disease mutation in the genetically normal kidney. BMC Nephrology, 13. ISSN 1471-2369
Abstract
Polycystic Kidney Disease (PKD) is a genetic condition in which dedifferentiated and highly proliferative epithelial cells form renal cysts and is frequently treated by renal transplantation. Studies have reported that bone marrow-derived cells give rise to renal epithelial cells, particularly following renal injury as often occurs during transplantation. This raises the possibility that bone marrow-derived cells from a PKD-afflicted recipient could populate a transplanted kidney and express a disease phenotype. However, for reasons that are not clear the reoccurrence of PKD has not been reported in a genetically normal renal graft. We used a mouse model to examine whether PKD mutant bone marrow-derived cells are capable of expressing a disease phenotype in the kidney.
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| Additional Information | Article 91 |
| Item type | Article |
| URI | https://vuir.vu.edu.au/id/eprint/23275 |
| DOI | 10.1186/1471-2369-13-91 |
| Official URL | http://www.biomedcentral.com/content/pdf/1471-2369... |
| Subjects | Historical > FOR Classification > 1103 Clinical Sciences Current > Division/Research > College of Health and Biomedicine |
| Keywords | ResPubID25687, mice, bone marrow-derived epithelial cells, cysts, hematopoietic stem cells, polycystic kidney disease, proliferation, renal injury, kidneys |
| Citations in Scopus | 1 - View on Scopus |
| Download/View statistics | View download statistics for this item |
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