Sgk-1 is a positive regulator of constitutive albumin uptake in renal proximal tubule cells

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Hryciw, Deanne H, Kruger, Wade A, Briffa, Jessica F, Slattery, Craig, Bolithon, Adelyn, Lee, Aven and Poronnik, Philip (2012) Sgk-1 is a positive regulator of constitutive albumin uptake in renal proximal tubule cells. Cellular Physiology and Biochemistry, 30 (5). pp. 1215-1226. ISSN 1015-8987 (print) 1421-9778 (online)

Abstract

eceptor-mediated endocytosis of albumin by the renal proximal tubule requires a number of proteins including megalin/cubilin, sodium/hydrogen exchanger isoform 3 (NHE3) and ClC-5, as well as the PSD-95/Dlg/Zo-1 (PDZ) scaffold sodium/hydrogen exchanger regulatory factor 2 (NHERF2). Despite members from the AGC kinase family, v-Akt Murine Thymoma Viral Oncogene (Akt or Protein Kinase B) and Serum/Glucocorticoid regulated Kinase 1 (Sgk-1) regulating a number of essential proteins in the albumin handling pathway, their role in uptake is largely unknown.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/23419
DOI https://doi.org/10.1159/000343313
Official URL http://www.karger.com/Article/Pdf/343313
Subjects Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Current > Division/Research > College of Health and Biomedicine
Keywords ResPubID25530, proximal tubule, albumin, endocytosis, Sgk-1, NHE3, NHERF2
Citations in Scopus 8 - View on Scopus
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