The effect of cancer procoagulant on expression of metastatic and angiogenic markers in breast cancer and embryonic stem cell lines

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Kee, Nalise Low Ah, Naude, Ryno J, Blatch, Gregory L and Frost, Carminita L (2012) The effect of cancer procoagulant on expression of metastatic and angiogenic markers in breast cancer and embryonic stem cell lines. Biological Chemistry, 393 (3). pp. 113-121. ISSN 1431-6730 (print) 1437-4315 (online)

Abstract

Cancer procoagulant is present only in malignant tumours and the undifferentiated tissues of human placenta. Its possible role in angiogenesis and metastasis was investigated. Cancer procoagulant increased the steady-state mRNA level of L1 cell adhesion molecule (L1CAM) in MCF-7 breast cancer cells and E14 mouse embryonic stem cells (MESCs), while an increase in angiogenin mRNA was observed in MDA-MB-231 breast cancer cells. Furthermore, production of vascular endothelial growth factor (VEGF) protein in MCF-7 breast cancer cells and E14 MESCs, but decreased in MDA-MB-231 breast cancer cells. We conclude that cancer procoagulant could potentially play a part in angiogenesis in cancer and vascular development during embryonic development.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/23645
DOI https://doi.org/10.1515/hsz-2011-0177
Official URL http://www.degruyter.com/view/j/bchm.2012.393.issu...
Subjects Historical > FOR Classification > 0601 Biochemistry and Cell Biology
Current > Division/Research > College of Health and Biomedicine
Keywords ResPubID26527, angiogenesis, cancer procoagulant, metastasis, VEGF
Citations in Scopus 4 - View on Scopus
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