Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems

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Tacar, Oktay, Sriamornsak, Pornsak and Dass, Crispin R (2013) Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems. Journal of Pharmacy and Pharmacology, 65 (2). pp. 157-170. ISSN 0022-3573 (print) 2042-7158 (online)

Abstract

The frontline drug doxorubicin has been used for treating cancer for over 30 years. While providing a cure in select cases, doxorubicin causes toxicity to most major organs, especially life-threate ning cardiotoxicity, which forces the treatment to become dose-limiting.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/23703
DOI https://doi.org/10.1111/j.2042-7158.2012.01567.x
Official URL http://onlinelibrary.wiley.com/doi/10.1111/j.2042-...
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 1112 Oncology and Carcinogenesis
Historical > FOR Classification > 1115 Pharmacology and Pharmaceutical Sciences
Keywords ResPubID26676, ResPubID25795, cancer, cardiotoxicity, chemotherapy, doxorubicin, drugs, pharmaceuticals
Citations in Scopus 1337 - View on Scopus
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