Ban, Ke Chen, Singh, Harjit, Krishnan, R and Seow, Heng Fong (2004) Comparison of the Expression of b-Catenin in Hepatocellular Carcinoma in Areas With High and Low Levels of Exposure to Aflatoxin B1. Journal of Surgical Oncology, 86 (3). pp. 157-163. ISSN 0022-4790

Abstract

Background and Objectives: Previous studies showed that the frequency of bcatenin mutation was different in mice when induced by different chemicals. The aim of this study is to compare the expression of b-catenin and p53 in hepatocellular carcinoma (HCC) from areas with exposure to high and low levels of aflatoxin B1 (AFB1). Methods: Thirty-five and twenty HCC samples from Guangxi and Malaysia, respectively,were studied. The expression of b-catenin and p53 was determined by immunohistochemistry. Results: The overexpression of b-catenin was detected in 65.7% of HCC tissues and 37.1% in adjacent liver tissues samples from Guangxi, China. Similarly, overexpression of b-catenin was also detected in 60.0% of HCC tissues and in 35.0% of adjacent liver tissues samples from Malaysia. The overexpression of p53 was detected in 42.9% of HCC specimens from Guangxi and in 25.0% of HCC specimens from Malaysia. There was a relationship between the expression of b-catenin and hepatitis B virus (HBV) infection in the adjacent liver tissues in Guangxi, and between the expression of b-catenin and p53 in HCC tissues in Malaysia. Conclusions: The differences in the exposure to AFB1 did not affect the overexpression of b-catenin in the development of HBV-associated HCC.

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