The relationship between heat shock protein 72 expression in skeletal muscle and insulin sensitivity is dependent on adiposity

Full text for this resource is not available from the Research Repository.

Henstridge, Darren C, Forbes, Josephine M, Penfold, Sally A, Formosa, Melissa F, Dougherty, Sonia L, Gasser, Anna, de Courten, Maximilian, Cooper, Mark E, Kingwell, Bronwyn A and de Courten, Barbora (2010) The relationship between heat shock protein 72 expression in skeletal muscle and insulin sensitivity is dependent on adiposity. Metabolism, 59 (11). pp. 1556-1561. ISSN 0026-0495


Decreased gene expression of heat shock protein 72 (HSP72) in skeletal muscle is associated with insulin resistance in humans. We aimed to determine whether HSP72 protein expression in insulin-sensitive tissues is related to criterion standard measures of adiposity and insulin resistance in a young healthy human population free of hyperglycemia. Healthy participants (N = 17; age, 30 ± 3 years) underwent measurement of body composition (dual-energy x-ray absorptiometry), a maximum aerobic capacity test (V̇o2max), an oral glucose tolerance test, and a hyperinsulinemic-euglycemic clamp (M) to access insulin sensitivity. Skeletal muscle and subcutaneous adipose tissue biopsies were obtained by percutaneous needle biopsy. HSP72 protein expression in skeletal muscle was inversely related to percentage body fat (r = −0.54, P < .05) and remained significant after adjustment for age and sex (P < .05). Insulin sensitivity was also related to HSP72 protein expression in skeletal muscle (r = 0.52, P < .05); however, this relationship disappeared after adjustment for percentage body fat (P = .2). In adipose tissue, HSP72 protein expression was not related to adiposity or insulin sensitivity. Physical activity and aerobic fitness did not show any association with HSP72 protein expression in either tissue studied. A lower expression of HSP72 protein in human skeletal muscle was associated with increased adiposity and decreased insulin sensitivity in healthy individuals. These findings are consistent with rodent data suggesting that HSP72 stimulates fat oxidation with consequent reduction in fat storage and adiposity.

Dimensions Badge

Altmetric Badge

Item type Article
DOI 10.1016/j.metabol.2010.01.027
Official URL
Subjects Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Historical > FOR Classification > 1103 Clinical Sciences
Current > Division/Research > College of Health and Biomedicine
Keywords heat shock protein, skeletal muscle, adipose tissue, insulin resistance
Citations in Scopus 24 - View on Scopus
Download/View statistics View download statistics for this item

Search Google Scholar

Repository staff login