Potential Mechanisms for Reduced Delivery of Nitric Oxide to Peripheral Tissues in Diabetes Mellitus

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Stabler, Thomas, Kenjale, Aarti A, Ham, Katherine L, Jelesoff, Nicole and Allen, Jason (2010) Potential Mechanisms for Reduced Delivery of Nitric Oxide to Peripheral Tissues in Diabetes Mellitus. Annals of the New York Academy of Sciences, 1203. pp. 101-106. ISSN 0077-8923 (print) 1749-6632 (online)

Abstract

Nitric oxide (NO) bioavailability is crucial for normal vascular endothelial function and health. Recent studies have demonstrated an endocrine role for NO equivalents that may be transported in the blood to peripheral tissue beds, where under hypoxic conditions they can liberate NO and cause vasodilation. Exercise training improves endothelial function but its effect on NO bioavailability in peripheral tissues during acute exercise stress in CVD is unclear. This paper will present evidence and discuss possible mechanisms by which NO delivery to peripheral tissues may be dysfunctional in diabetic subjects.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/25756
DOI https://doi.org/10.1111/j.1749-6632.2010.05599.x
Official URL http://onlinelibrary.wiley.com/doi/10.1111/j.1749-...
Subjects Historical > FOR Classification > 1103 Clinical Sciences
Historical > FOR Classification > 1106 Human Movement and Sports Science
Current > Division/Research > College of Sports and Exercise Science
Keywords nitric oxide, diabetes mellitus, vascular
Citations in Scopus 17 - View on Scopus
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