Time Course of Improved Flow-Mediated Dilation after Short-Term Exercise Training

Full text for this resource is not available from the Research Repository.

Allen, Jason, Greenway, Frank, Geaghan, James P and Welsch, Michael A (2003) Time Course of Improved Flow-Mediated Dilation after Short-Term Exercise Training. Medicine and Science in Sports and Exercise, 35 (5). pp. 847-853. ISSN 0195-9131 (print) 1530-0315 (online)


Purpose: The purpose was to determine the influence of a unilateral localized short-term handgrip training protocol on brachial artery flow-mediated dilation (BAFMD) and to examine the time course of such changes. Methods: Fourteen healthy males (age: 26 ± 5.7 yr) underwent high-resolution ultrasonographic brachial artery assessments before (V1), during (V2–V7), and at the end of 4 wk (V8) of 60% maximal voluntary contraction handgrip training (20 min·d-1, 5 d·wk-1) of the nondominant arm. Results: Before training resting diameters were similar between the trained (nondominant) and untrained (dominant) arms. A 2 (trained and untrained arms) × 2 (V1 and V8) repeated measure ANOVA revealed a significant main (P = 0.02 and P = 0.03) and interaction effect (P = 0.05 and P = 0.01) for the percent and absolute change in BAFMD. BAFMD improved 62% and 70%, respectively from V1 to V8, for the percent and absolute change. Subsequent linear orthogonal polynomial contrasts indicate both the percent and absolute change in BAFMD were statistically different at V2 (end of week 1 and 4 training days) from V1. These unilateral changes were not accompanied by changes in resting artery diameter, hemodynamic measures, hematological markers, and indices of heart rate variability suggesting the change may be locally mediated. Conclusions: This study shows a localized short-term exercise-training program resulted in significant improvements in BAFMD in the trained arm compared with the untrained arm and suggests this occurred after only 4 d of training.

Dimensions Badge

Altmetric Badge

Item type Article
URI https://vuir.vu.edu.au/id/eprint/25768
DOI 10.1249/01.MSS.0000064931.62916.8A
Official URL http://dx.doi.org/10.1249/01.MSS.0000064931.62916....
Subjects Historical > FOR Classification > 1102 Cardiorespiratory Medicine and Haematology
Historical > FOR Classification > 1106 Human Movement and Sports Science
Current > Division/Research > College of Sports and Exercise Science
Keywords brachial, artery, vasoreactivity, endothelium
Citations in Scopus 58 - View on Scopus
Download/View statistics View download statistics for this item

Search Google Scholar

Repository staff login