A complementary role for the tetraspanins CD37 and Tssc6 in the immune system

Gartlan, Kate Helen (2008) A complementary role for the tetraspanins CD37 and Tssc6 in the immune system. PhD thesis, Victoria University.

Abstract

The co-operative nature of tetraspanin-tetraspanin interactions in membrane organisation suggests that functional overlap is likely to be a factor in tetraspanin biology. CD37 and Tssc6 are immune/haematopoietic restricted tetraspanins, whose function has been previously investigated with CD37"7" and TSSC6"7" knockout mice. Both strains display hyper-proliferative T cell responses to in vitro stimulation, suggesting that functional overlap may occur between these two tetraspanin molecules in the immune system. To test this hypothesis, the immunophenotype of a tetraspanin "double knockout' mouse (CDST^Tssce-7") is described.

Item type Thesis (PhD thesis)
URI https://vuir.vu.edu.au/id/eprint/29497
Subjects Current > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Historical > Faculty/School/Research Centre/Department > School of Engineering and Science
Keywords membrane proteins, T cells, B cells, NKT cells, molecules, lymphocytes, in vivo DC migration, in vitro cellular immunity
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