Pigment epithelium-derived factor: a multimodal tumor inhibitor

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Ek, Eugene T. H, Dass, Crispin R and Choong, Peter F. M (2006) Pigment epithelium-derived factor: a multimodal tumor inhibitor. Molecular Cancer Therapeutics , 5 (7). pp. 1641-1646. ISSN 1535-7163


Pigment epithelium-derived factor (PEDF), a noninhibitory member of the serine protease inhibitor (serpin) family, is a well-known potent endogenous inhibitor of angiogenesis. It has been known for years to be aberrantly expressed in ocular disorders, but in recent years, down-regulation has been shown to be prevalent in a range of cancers as well. This review describes the trimodal anticancer activities of this interesting protein: antiangiogenesis, apoptosis-mediated tumor suppression, and tumor cell differentiation. The key to successful antitumor therapy with this protein is the ability to synthesize the recombinant form of the protein (or its active shortened forms) and deliver at therapeutic doses or alternatively to use gene transfer technology to prolong the effect in vivo. Although there is a substantial amount of work carried out at the preclinical stage with this protein, more groundwork has to be done before PEDF is tested against cancer in clinical trials

Item type Article
URI https://vuir.vu.edu.au/id/eprint/2968
Official URL http://mct.aacrjournals.org/content/5/7/1641.full....
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 1112 Oncology and Carcinogenesis
Keywords ResPubID18888, PEDF, tumor angiogenesis, cancer therapy
Citations in Scopus 72 - View on Scopus
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