Effects of high-intensity training on components of muscle pH regulation

McGinley, Cian (2015) Effects of high-intensity training on components of muscle pH regulation. PhD thesis, Victoria University.


Regulation of pH in skeletal muscle comprises intracellular buffering of hydrogen ions (H+) and acid/base (H+/HCO3−) transport across the sarcolemma. During high-intensity exercise H+ transport is primarily lactate-coupled through the monocarboxylate transporters (MCT)1/4, with non-lactate-coupled transport provided by the sodium/hydrogen exchanger (NHE) system. The chaperone protein basigin is essential for MCT functioning. Intracellular buffering comprises metabolic and physicochemical buffering (βm), the latter mainly from the histidine-based proteins and dipeptides, and inorganic phosphate. The sodium-coupled bicarbonate transport proteins (NCBT) enhance intracellular buffering and H+ efflux, while the cytosolic and sarcolemmal carbonic anhydrase (CA) isozymes may enhance activity of each transport system by physical or functional interactions.

Item type Thesis (PhD thesis)
URI https://vuir.vu.edu.au/id/eprint/31023
Subjects Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Historical > FOR Classification > 1106 Human Movement and Sports Science
Current > Division/Research > College of Sports and Exercise Science
Keywords intense exercise, muscles, isoforms, acid, biopsies, acid/base transport, transporters, acid-base, transmembrane, sprints, repeated sprint ability
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