The combination of high dietary methionine plus cholesterol induces myocardial fibrosis in rabbits

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Zulli, Anthony, Hare, David L, Buxton, Brian F and Black, M. Jane (2006) The combination of high dietary methionine plus cholesterol induces myocardial fibrosis in rabbits. Atherosclerosis, 185 (2). pp. 278-281. ISSN 0021-9150


Limited evidence suggests that myocardial fibrosis might be associated with dietary cardiovascular risk factors. OBJECTIVE: To investigate the effects of high dietary cholesterol, methionine (the precursor to homocysteine), and the combination of the two diets on myocardial fibrosis. METHODS: Rabbits were randomly allocated into four dietary groups for 12 weeks: control (Con), 1% methionine (Meth), 0.5% cholesterol (Chol) or 1% methionine plus 0.5% cholesterol (MethChol). RESULTS: Myocardial fibrosis was not significantly increased in Chol or Meth. However, interstitial fibrosis increased by 85% (p = 0.03) and perivascular fibrosis 28-fold (p < 0.01) in the MethChol group compared to Con. CONCLUSIONS: These results suggest that high levels of dietary cholesterol or methionine alone do not significantly increase myocardial collagen content. However, the combination of the two diets does cause myocardial fibrosis. Therefore, excessive cholesterol and methionine intake may be an important pathogenic factor in the development of myocardial fibrosis.

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Item type Article
DOI 10.1016/j.atherosclerosis.2005.06.036
Official URL
Subjects Historical > FOR Classification > 1102 Cardiorespiratory Medicine and Haematology
Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Keywords ResPubID17584, cholesterol, homocysteine, myocardial fibrosis
Citations in Scopus 9 - View on Scopus
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