Setting the Stage: From Prodrome to Treatment Resistance in Bipolar Disorder

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Berk, Michael, Consus, Philippe, Lucas, Nellie, Hallam, Karen, Malhi, Gin S, Dodd, Seetal, Yatham, Lakshmi N, Yung, Alison and McGorry, Pat (2007) Setting the Stage: From Prodrome to Treatment Resistance in Bipolar Disorder. Bipolar Disorders, 9 (7). pp. 671-678. ISSN 1398-5647


Bipolar disorder is common, and both difficult to detect and diagnose. Treatment is contingent on clinical needs, which differ according to phase and stage of the illness. A staging model could allow examination of the longitudinal course of the illness and the temporal impact of interventions and events. It could allow for a structured examination of the illness, which could set the stage for algorithms that are tailored to the individuals needs. A staging model could further provide as structure for assessment, gauging treatment and outcomes. The model incorporates prodromal stages and emphasizes early detection and algorithm appropriate intervention where possible. At the other end of the spectrum, the model attempts to operationalize treatment resistance. The utility of the model will need to be validated by empirical research.

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Item type Article
DOI 10.1111/j.1399-5618.2007.00484.x
Official URL
Subjects Historical > FOR Classification > 1103 Clinical Sciences
Historical > FOR Classification > 1701 Psychology
Historical > Faculty/School/Research Centre/Department > School of Social Sciences and Psychology
Keywords ResPubID16563, bipolar disorder, early intervention, management, prodrome, stages, treatment resistance
Citations in Scopus 187 - View on Scopus
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