The effects of Caralluma Fimbriata on appetite behaviour and associated neural pathways in Prader-Willi syndrome

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Griggs, Joanne Louise (2016) The effects of Caralluma Fimbriata on appetite behaviour and associated neural pathways in Prader-Willi syndrome. PhD thesis, Victoria University.

Abstract

Prader-Willi syndrome (PWS) is defined by simultaneously non-functioning genes on the paternal chromosome in the critical region 15q11.2–q13, which includes five small nucleolar RNA (SnoRNA), one of which is of interest to this thesis: SnoRNA116/HBII-85. The syndrome has a prevalence of 1:15,000 – 1: 30,000 and the complex physical, behavioural and intellectual difficulties are characterized through four phenotypic phases that correlate with age. Though these phases are individualized in timing and severity, all with PWS will experience phase three: hyperphagia (mean: - 8 years of age) and will need multiple, life-long intervention programs against the prediction of obesity.

Item type Thesis (PhD thesis)
URI https://vuir.vu.edu.au/id/eprint/32221
Subjects Historical > FOR Classification > 1109 Neurosciences
Historical > FOR Classification > 1110 Nursing
Historical > FOR Classification > 1115 Pharmacology and Pharmaceutical Sciences
Historical > Faculty/School/Research Centre/Department > Centre for Chronic Disease Prevention and Management
Current > Division/Research > College of Health and Biomedicine
Keywords PWS, appetite control, regulation, neurology, appetite suppressants
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