GFP expression alters osteosarcoma cell biology

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Dass, Crispin R and Choong, Peter F. M (2007) GFP expression alters osteosarcoma cell biology. DNA Cell Biology, 26 (8). pp. 599-601. ISSN 1044-5498


Green fluorescent protein (GFP) expression is widely used for tracking of cells in vivo. Three human osteosarcoma cell lines were transfected with GFP and analyzed for expression of tissue markers and physiology. GFP-mediated increased tumor aggression in vivo in one cell line was corroborated by altered expression of bone markers and osteoblast-like cell biology in vitro as a result of transfection. The use of GFP for cell tracking in osteosarcoma animal models should therefore be used with caution.

Item type Article
Subjects Historical > FOR Classification > 1112 Oncology and Carcinogenesis
Historical > FOR Classification > 1115 Pharmacology and Pharmaceutical Sciences
Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Keywords ResPubID18876, green fluorescent protein (GFP), cells in vivo, human osteosarcoma cell lines, tumor aggression, bone markers, cell tracking
Citations in Scopus 15 - View on Scopus
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