The Effects of Dietary Supplements on Skeletal Muscle Function in Type 2 Diabetic Rats

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Pompeani, Nancy (2016) The Effects of Dietary Supplements on Skeletal Muscle Function in Type 2 Diabetic Rats. PhD thesis, Victoria University.


Type 2 Diabetes is considered to be a heterogeneous disease, and whilst its pathogenesis is currently unknown, it is often characterized by high plasma free fatty acids (FFAs), hyperglycaemia, and altered insulin secretion from pancreatic β-cells. Whilst multiple organ systems are often affected by the disease, the effects on skeletal muscle in particular are pertinent, as this is the main organ responsible for glucose disposal, and also has a major role in basal and altered metabolism. The overall aim of this thesis is to examine the extent of any changes to skeletal muscle morphology and (dys)function in Type 2 Diabetes and how these can be improved by the use of dietary supplements. Specifically, the potential of Creatine Monohydrate, Whey Protein Isolate, and Aspirin on the contractile apparatus and specific intramyocellular organelles will be tested in order to reverse some of the maladaptations found in skeletal muscle of Type 2 Diabetic patients.

Item type Thesis (PhD thesis)
Subjects Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Historical > FOR Classification > 1106 Human Movement and Sports Science
Historical > FOR Classification > 1111 Nutrition and Dietetics
Current > Division/Research > College of Health and Biomedicine
Keywords skeletal muscles, muscle atrophy, muscle function, therapies, supplementation, fatigue, metabolites, metabolism
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