Effects of Caralluma fimbriata extract on cardiovascular and metabolic disorders

Astell, Katie J (2016) Effects of Caralluma fimbriata extract on cardiovascular and metabolic disorders. PhD thesis, Victoria University.


Central obesity, insulin resistance, atherogenic dyslipidemia and elevated blood pressure are the major components of metabolic syndrome. This complex disorder is considered to be a clinical challenge and an urgent public health issue. With the growing prevalence of obesity worldwide, effective strategies are needed to intervene in the development and progression of metabolic syndrome. Despite the short-term benefits of pharmaceutical treatment of obesity, current drug therapy is associated with adverse side effects, thus the use of complementary and alternative therapies has become increasingly popular among the general population as an alternative method for weight loss. Botanical extracts in combination with lifestyle modification may be effective agents for attenuating the development of metabolic syndrome as they often comprise of a vast range of bioactive compounds that have been associated with significant positive health outcomes with minimal side effects. However, the efficacy of many of these extracts and their chemical constituents have yet to be fully explored. The research presented in this thesis examines the effectiveness of two commonly used anti-obesity botanical extracts, namely Caralluma fimbriata and Citrus sinensis (Moro variety). The primary aim of this PhD project was to investigate the efficacy of C. fimbriata extract on the risk factors of metabolic syndrome in overweight and obese conditions.

Item type Thesis (PhD thesis)
URI https://vuir.vu.edu.au/id/eprint/33252
Subjects Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Historical > FOR Classification > 1102 Cardiorespiratory Medicine and Haematology
Historical > FOR Classification > 1104 Complementary and Alternative Medicine
Historical > FOR Classification > 1111 Nutrition and Dietetics
Historical > Faculty/School/Research Centre/Department > Centre for Chronic Disease Prevention and Management
Current > Division/Research > College of Health and Biomedicine
Keywords metabolic syndrome, diet, nutrition, metabolism, natural medicine, risk factors, supplements, supplementation, citrus sinensis extract, rats, atherosclerotic indices, C. sinensis, C. fimbriata
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