Understanding the role of MasR in vascular pathology

Rai, Sudarshan (2016) Understanding the role of MasR in vascular pathology. Research Master thesis, Victoria University.

Abstract

Homocysteine was first suggested as a risk to CVD in 1969. Since then, elevated plasma homocysteine (derived from methionine) has remained a cardiovascular risk factor with no current treatment. Homocysteine is known to stimulate NADPH oxidase, and NADPH oxidase can be inhibited by stimulation of the Mas receptor (MasR) of the renin angiotensin system. Stimulation of MasR is known to reduce organ fibrosis through the production of NO. However, the role that MasR plays in homocysteine-induced vascular pathology, including endothelial dysfunction and organ fibrosis, is not known. The aim of this thesis is to determine if high methionine diet in MasR-/- mice will worsen cardiovascular pathology.

Additional Information

Master of Science (Research)

Item type Thesis (Research Master thesis)
URI https://vuir.vu.edu.au/id/eprint/35026
Subjects Current > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Current > FOR Classification > 1102 Cardiorespiratory Medicine and Haematology
Current > Division/Research > College of Health and Biomedicine
Keywords cardiovascular disease, CVD, endothelial function, myocardial fibrosis, immunochemistry, renal disease, risk factors, receptors
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