Central nitric oxide synthase inhibition restores behaviourally mediated lipopolysaccharide-induced fever in near-term rats

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Begg, Denovan P, Mathai, Michael ORCID: 0000-0001-8783-2122, McKinley, MJ, Frappell, Peter B and Kent, Stephen (2008) Central nitric oxide synthase inhibition restores behaviourally mediated lipopolysaccharide-induced fever in near-term rats. Physiology and Behavior, 94 (4). pp. 630-634. ISSN 0031-9384

Abstract

It has recently been established that the febrile response to bacterial endotoxin attenuated late in pregnancy is partially restored by central inhibition of nitric oxide synthase (NOS). To determine if this restoration of the febrile response also extends to warm-seeking behavior, we used a thermocline to allow animals to select their preferred ambient temperature. Near-term pregnant (day 19–20) and aged matched non-pregnant rats were given an I.P. injection of lipopolysaccharide (LPS, 50 μg/kg) and an intracerebroventricular (I.C.V.) injection of an inhibitor of NOS, NG-monomethyl-L-arginine acetate salt (L-NMMA, 100 μg) or vehicle. Core body temperature and self-selected ambient temperature were measured for 6 h after injection. Inhibition of brain NOS before LPS injection resulted in a significant febrile response with an associated increase in selected ambient temperature in both near-term and non-pregnant animals. As expected, near-term dams that received I.C.V. vehicle+I.P. LPS did not have a febrile response but displayed a small hypothermic reaction with no change in selected ambient temperature. We conclude that blockade of brain NOS restores maternal hyperthermic and warm-seeking responses to LPS in near-term pregnancy.

Item type Article
URI https://vuir.vu.edu.au/id/eprint/3506
Official URL http://www.sciencedirect.com/science/article/pii/S...
Subjects Current > FOR Classification > 0606 Physiology
Current > FOR Classification > 0608 Zoology
Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Keywords ResPubID16330, fever, nitric oxide, pregnant, behavioral thermoregulation, thermal gradient
Citations in Scopus 6 - View on Scopus
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