Biocompatible chitosan-DNAzyme nanoparticle exhibits enhanced biological activity

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Dass, Crispin R, Friedhuber, Anna M, Khachigian, Levon M, Dunstan, David E and Choong, Peter F. M (2008) Biocompatible chitosan-DNAzyme nanoparticle exhibits enhanced biological activity. Journal of Microencapsulation, 25 (6). pp. 421-425. ISSN 0265-2048


DNAzymes are oligonucleotides capable of specific catalysis of target mRNA. To date, a delivery vehicle for DNAzymes has not been developed. Chitosan is a biomaterial obtained abundantly in nature. A biocompatible c-jun (an oncogene) DNAzyme nanoparticle formulated from chitosan was found to be more active against osteosarcoma (bone cancer) cells, inducing apoptotic cell death in these cells. The formulation was stable in serum for a week and at room temperature for a month. Clinically, knockdown of c-jun gene expression with chitosan nanobiotechnology may improve treatment outcome for tumours growing in bone

Item type Article
Subjects Historical > RFCD Classification > 320000 Medical and Health Sciences
Historical > FOR Classification > 1117 Public Health and Health Services
Historical > FOR Classification > 1115 Pharmacology and Pharmaceutical Sciences
Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Keywords ResPubID18861. Chitosan, c-jun, apoptosis, deoxyribozyme, nanoparticle, bone cancer cells
Citations in Scopus 30 - View on Scopus
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