Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model

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Dass, Crispin R, Friedhuber, Anna M, Khachigian, Levon M, Dunstan, David E and Choong, Peter F. M (2008) Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model. Cancer Biology and Therapy, 7 (7). pp. 1033-1036. ISSN 1538-4047

Abstract

c-jun has been found to be upregulated in a variety of cancers including osteosarcoma. DNAzymes are oligonucleotides capable of specific downregulation of target genes. c-jun knockdownmediated apoptosis in osteosarcoma cells involved caspases-1, -2 and -8, but not the Fas/FasL pathway. A c-jun DNAzyme, encapsulated within a novel cationic multilamellar vesicle liposome, inhibited the growth and metastasis of osteosarcoma in an orthotopic spontaneously metastasising model of the disease. The 60 nm DDAB:DOPE liposome was formulated using ethanol injection/ extrusion. Clinically, downregulation of c-jun may proffer an improved treatment outcome for these tumors originating in bone.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/3597
DOI https://doi.org/10.4161/cbt.7.7.6037
Official URL http://www.landesbioscience.com/journals/cbt/artic...
Subjects Historical > RFCD Classification > 320000 Medical and Health Sciences
Historical > FOR Classification > 1117 Public Health and Health Services
Historical > FOR Classification > 1115 Pharmacology and Pharmaceutical Sciences
Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Keywords ResPubID18860. c-jun, cancer, apoptosis, deoxyribozyme, osteosarcoma, liposome
Citations in Scopus 26 - View on Scopus
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