Involvement of c-jun in human liposarcoma growth: supporting data from clinical immunohistochemistry and DNAzyme efficacy
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Dass, Crispin R, Galloway, Stuart J, Clark, Jonathan C. M, Khachigian, Levon M and Choong, Peter F. M (2008) Involvement of c-jun in human liposarcoma growth: supporting data from clinical immunohistochemistry and DNAzyme efficacy. Cancer Biology and Therapy, 7 (8). pp. 1297-1301. ISSN 1538-4047
Abstract
c-jun has been found to be upregulated in a variety of cancers. Recently, this oncogene has also been implicated in liposarcoma (LS) progression. c-jun knockdown mediated by a deoxyribozyme induced apoptosis in LS cells via evoking caspase-10, but not the Fas/FasL pathway. A novel orthotopic model for LS was established in the hindlimb of mice using human cells to extend the evaluation of effects of c-jun knockdown in vivo. Tumor take in vivo was 100%, with growths resembling high grade aggressive LS. The c-jun deoxyribozyme inhibited the growth of LS in this model. Clinically, downregulation of c-jun may proffer an improved treatment outcome for liposarcoma. The new model for LS described here will enable better testing of agents with therapeutic potential against LS.
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| Item type | Article |
| URI | https://vuir.vu.edu.au/id/eprint/3598 |
| DOI | 10.4161/cbt.7.8.6301 |
| Official URL | http://www.landesbioscience.com/journals/cbt/artic... |
| Subjects | Historical > RFCD Classification > 320000 Medical and Health Sciences Historical > FOR Classification > 1117 Public Health and Health Services Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences |
| Keywords | ResPubID18868. c-jun, cancer, apoptosis, deoxyribozyme, liposarcoma, orthotopic, gene therapy |
| Citations in Scopus | 26 - View on Scopus |
| Download/View statistics | View download statistics for this item |
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