Jayasooriya, Anura P, Begg, Denovan P, Chen, Nora, Mathai, Michael ORCID: 0000-0001-8783-2122, Sinclair, Andrew J, Wilkinson-Berka, J, Wark, John D, Weisinger, Harrison S and Weisinger, Richard S (2008) Omega-3 polyunsaturated fatty acid supplementation reduces hypertension in TGR (mRen-2)27 rats. Prostaglandins, Leukotrienes and Essential Fatty Acids, 78 (1). pp. 67-72. ISSN 0952-3278

Abstract

To establish the effect of dietary o-3 PUFA on angiotensin II (ANG II)-mediated hypertension, male TGR (mRen-2)27 (Ren-2) rats (animals with high ANG II activity) were maintained on a diet either deficient or sufficient in o-3 PUFA from conception. Half the animals on each diet were treated with the angiotensin-converting enzyme inhibitor, perindopril, from birth. Ren-2 rats fed the o-3 PUFA deficient diet were significantly more hypertensive than those fed the o-3 PUFA sufficient diet. Perindopril reduced the blood pressure of both o-3 PUFA-deficient and o-3 PUFA-sufficient diet-fed Ren-2 rats. Body weight, body fat and plasma leptin were reduced by perindopril treatment but not affected by o-3 PUFA supply. Given that the elevated blood pressure of the Ren-2 rat is mediated by ANG II, the data suggest that o-3 PUFA may reduce hypertension via the renin–angiotensin system.

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