Intranasal naloxone for the treatment of suspected heroin overdose

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Kerr, Debra, Dietze, Paul and Kelly, Anne-Maree (2008) Intranasal naloxone for the treatment of suspected heroin overdose. Addiction, 103 (3). pp. 379-386. ISSN 0965-2140


Aims - This paper reviews available literature regarding the effectiveness, safety and utility of intranasal (i.n.) naloxone for the treatment of heroin overdose. Methods - Scientific literature in the form of published articles during the period January 1984 to August 2007 were identified by searching several databases including Medline, Cinahl and Embase for the following terms: naloxone, narcan, intranasal, nose. The data extracted included study design, patient selection, numbers, outcomes and adverse events. Results - Reports of the pharmacological investigation and administration of i.n. naloxone for heroin overdose are included in this review. Treatment of heroin overdose by administration of i.n. naloxone has been introduced as first-line treatment in some jurisdictions in North America, and is currently under investigation in Australia. Conclusion - Currently there is not enough evidence to support i.n. naloxone as first-line intervention by paramedics for treatment of heroin overdose in the pre-hospital setting. Further research is required to confirmits clinical effectiveness, safety and utility. If proved effective, the i.n. route may be useful for drug administration in community settings (including peer-based administration), as it reduces risk of needlestick injury in a population at higher risk of blood-borne viruses. Problematically, naloxone is not manufactured currently in an ideal form for i.n. administration.

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Item type Article
DOI 10.1111/j.1360-0443.2007.02097.x
Official URL
Subjects Historical > Faculty/School/Research Centre/Department > School of Nursing and Midwifery
Historical > FOR Classification > 1117 Public Health and Health Services
Historical > SEO Classification > 9202 Health and Support Services
Keywords ResPubID14766, heroin, intranasal, naloxone, opioid, overdose, paramedic, resuscitation
Citations in Scopus 34 - View on Scopus
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