Exercise Training, Immobilisation and Castration Effects on Skeletal Muscle Na+,K+-ATPase

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Altarawneh, Muath (2018) Exercise Training, Immobilisation and Castration Effects on Skeletal Muscle Na+,K+-ATPase. PhD thesis, Victoria University.

Abstract

The Na+,K+-ATPase (NKA) is a key protein involved in the maintenance of skeletal muscle excitability during contractions, and comprises two subunits (α and β), each of which are expressed as multiple isoforms in skeletal muscle (α1 - α3 and β1 - β3). Therefore any modulation of NKA content or of individual NKA isoforms has the potential to affect muscle function. This thesis comprises four studies that investigated the effects of conditions intended to induce downregulation or upregulation of the NKA in skeletal muscle, utilising hindlimb immobilisation, testosterone suppression and increased physical activity through various training regimes. A theme of the thesis was specific effects of changes in physical activity and on muscle NKA.

Item type Thesis (PhD thesis)
URI http://vuir.vu.edu.au/id/eprint/37819
Subjects Current > FOR Classification > 1106 Human Movement and Sports Science
Current > Division/Research > Institute for Health and Sport
Keywords sodium-potassium adenosine triphosphatase; NKA; skeletal muscle; immobilization; testosterone; physical activity; resistance training; moderate intensity continuous training; MICT; high intensity interval exercise training; HIITT; kidney disease
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