Recent advances in understanding the role of FOXO3
Download
Download
DownloadPreview
Recent advances in understanding the role of FOXO3.pdf
- Published Version
(1MB)
| Preview
Available under license: Creative Commons Attribution
Export
Stefanetti, Renae J, Voisin, Sarah 
ORCID: 0000-0002-4074-7083, Russell, Aaron and Lamon, Séverine
(2018)
Recent advances in understanding the role of FOXO3.
F1000Research, 7.
ISSN 2046-1402
Abstract
The forkhead box O3 (FOXO3, or FKHRL1) protein is a member of the FOXO subclass of transcription factors. FOXO proteins were originally identified as regulators of insulin-related genes; however, they are now established regulators of genes involved in vital biological processes, including substrate metabolism, protein turnover, cell survival, and cell death. FOXO3 is one of the rare genes that have been consistently linked to longevity in in vivo models. This review provides an update of the most recent research pertaining to the role of FOXO3 in (i) the regulation of protein turnover in skeletal muscle, the largest protein pool of the body, and (ii) the genetic basis of longevity. Finally, it examines (iii) the role of microRNAs in the regulation of FOXO3 and its impact on the regulation of the cell cycle.
Dimensions Badge
Altmetric Badge
| Item type | Article |
| URI | https://vuir.vu.edu.au/id/eprint/38231 |
| DOI | 10.12688/f1000research.15258.1 |
| Official URL | https://f1000research.com/articles/7-1372/v1 |
| Subjects | Historical > FOR Classification > 0604 Genetics Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics Current > Division/Research > Institute for Health and Sport |
| Keywords | FOXO3; longevity; microRNA; protein turnover; skeletal muscle; transcription factor |
| Citations in Scopus | 48 - View on Scopus |
| Download/View statistics | View download statistics for this item |
CORE (COnnecting REpositories)