Recent advances in understanding the role of FOXO3

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Stefanetti, Renae J, Voisin, Sarah ORCID: 0000-0002-4074-7083, Russell, Aaron and Lamon, Séverine (2018) Recent advances in understanding the role of FOXO3. F1000Research, 7. ISSN 2046-1402

Abstract

The forkhead box O3 (FOXO3, or FKHRL1) protein is a member of the FOXO subclass of transcription factors. FOXO proteins were originally identified as regulators of insulin-related genes; however, they are now established regulators of genes involved in vital biological processes, including substrate metabolism, protein turnover, cell survival, and cell death. FOXO3 is one of the rare genes that have been consistently linked to longevity in in vivo models. This review provides an update of the most recent research pertaining to the role of FOXO3 in (i) the regulation of protein turnover in skeletal muscle, the largest protein pool of the body, and (ii) the genetic basis of longevity. Finally, it examines (iii) the role of microRNAs in the regulation of FOXO3 and its impact on the regulation of the cell cycle.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/38231
DOI https://doi.org/10.12688/f1000research.15258.1
Official URL https://f1000research.com/articles/7-1372/v1
Subjects Current > FOR Classification > 0604 Genetics
Current > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Current > Division/Research > Institute for Health and Sport
Keywords FOXO3; longevity; microRNA; protein turnover; skeletal muscle; transcription factor
Citations in Scopus 17 - View on Scopus
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