Recent advances in understanding the role of FOXO3

[thumbnail of Recent advances in understanding the role of FOXO3.pdf]
Available under license: Creative Commons Attribution

Stefanetti, Renae J, Voisin, Sarah ORCID: 0000-0002-4074-7083, Russell, Aaron and Lamon, Séverine (2018) Recent advances in understanding the role of FOXO3. F1000Research, 7. ISSN 2046-1402


The forkhead box O3 (FOXO3, or FKHRL1) protein is a member of the FOXO subclass of transcription factors. FOXO proteins were originally identified as regulators of insulin-related genes; however, they are now established regulators of genes involved in vital biological processes, including substrate metabolism, protein turnover, cell survival, and cell death. FOXO3 is one of the rare genes that have been consistently linked to longevity in in vivo models. This review provides an update of the most recent research pertaining to the role of FOXO3 in (i) the regulation of protein turnover in skeletal muscle, the largest protein pool of the body, and (ii) the genetic basis of longevity. Finally, it examines (iii) the role of microRNAs in the regulation of FOXO3 and its impact on the regulation of the cell cycle.

Dimensions Badge

Altmetric Badge

Item type Article
DOI 10.12688/f1000research.15258.1
Official URL
Subjects Historical > FOR Classification > 0604 Genetics
Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Current > Division/Research > Institute for Health and Sport
Keywords FOXO3; longevity; microRNA; protein turnover; skeletal muscle; transcription factor
Citations in Scopus 48 - View on Scopus
Download/View statistics View download statistics for this item

Search Google Scholar

Repository staff login