Injectable chitosan hydrogels for localised cancer therapy

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Ta, Hang T, Dass, Crispin R and Dunstan, David E (2008) Injectable chitosan hydrogels for localised cancer therapy. Journal of Controlled Release, 126 (3). pp. 205-216. ISSN 0168-3659


The pace of development of delivery systems that could target drugs to specific body sites and control the release of drugs for prolonged periods of time have been steady though slow. Till a decade ago, mostly microspheres or nanoparticles were widely studied and applied in cancer treatment. However, due to shortcomings of these systems, there has been a surge in interest for in situ hydrogels. This review focuses on the current use of injectable in situ chitosan hydrogels in cancer treatment. Formulation protocols for in situ hydrogel systems, their cytotoxic properties, loading and in vitro release of drugs, their effect on cell growth in vitro and inhibition of tumor growth in vivo using mouse models, and future directions to enhance this technology are discussed.

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Item type Article
DOI 10.1016/j.jconrel.2007.11.018
Official URL
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 0903 Biomedical Engineering
Historical > FOR Classification > 1112 Oncology and Carcinogenesis
Keywords ResPubID18863, chitosan, hydrogel, controlled release, cancer, drug delivery, therapy
Citations in Scopus 243 - View on Scopus
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